Oestrogens, Progestins and Combinations

Effect of Lyndiol, an oral contraceptive, on breast cancer.

Recent papers have reported small clinical trials of progestins in combination with oestrogens in the treatment of advanced breast cancer (Landau et al., 1962 ; Stoll, 1965 ; Crowley and MacDonald, 1965). This form of combination therapy is based upon experimental observations in rats made by Huggins et al. (1962). The clinical reports to date suggest that a beneficial response may be expected ...

The differential effects of oestrogens and progestins on vascular tone.

The purpose of this paper is to present reported findings of the effects of ovarian steroids on vascular tone. The medical literature was reviewed for relevant contributions. Oestrogen replacement therapy in postmenopausal women is associated with a reduction in mortality from coronary artery disease. Many different cellular actions have been described which help explain the cardioprotective ef...

Effects of progestogens on thrombosis and atherosclerosis.

In contrast with past practice, current hormone replacement usually includes a combination of oestrogens and progestogens. In this article, we review the effect of progestins on haemostasis and in the development of atherosclerosis. Second-generation progestogens produce minor haemostatic changes, and in lipid metabolism they decrease the synthesis of triglycerides and very low density lipoprot...

Oestrogens, progestogens and the occurrence and acceptability of vaginal bleeding

Differential effects of progestins on the circulating IGF-I system.

OBJECTIVE Circulating insulin-like growth factor-I (IGF-I) is mainly produced by the liver under GH stimulation and is influenced by nutrition and insulin. IGF-I bioavailability is regulated by interactions with specific binding proteins (IGFBPs). The objective of this paper is to review available data on modifications of the IGF-I system in menopausal women during HRT, with particular attentio...